Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to SN1 and SN2 Processes
نویسنده
چکیده
Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (SN1 and SN2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transition-metal complexes provide an attractive approach to addressing these limitations.
منابع مشابه
Enantio-Convergent Nucleophilic Substitution Reaction of Racemic Electrophiles Catalyzed by Chiral Brønsted Acid
Among the methods for asymmetric synthesis, enantioselective catalysis is one of the representatives to produce enantio-enriched molecules in an efficient and practical manner. Catalytic enantioselective nucleophilic addition to pro-chiral electrophiles such as aldehydes, ketones, imines, and electron deficient double bonds is one of the most extensively investigated reactions, and substantial ...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2017